Lactic acidosis in biguanide-treated diabetics
نویسندگان
چکیده
منابع مشابه
Association of lactic acidosis with biguanide therapy.
To the Editor: In recent months an increasing number of patients have been referred to us by doctors from outside with a standard note: ' breathlessness ... tiredness anaemia (4 8 g/IOO mJ) blood transfusion given .. Hb now 12 g/IOO ml please see and treat'. Many of these patients have required urgent blood-leiting and dialysis for iatrogenic pulmonary oedema and renal failure. Few doctors real...
متن کاملOxygen consumption is depressed in patients with lactic acidosis due to biguanide intoxication
INTRODUCTION Lactic acidosis can develop during biguanide (metformin and phenformin) intoxication, possibly as a consequence of mitochondrial dysfunction. To verify this hypothesis, we investigated whether body oxygen consumption (VO2), that primarily depends on mitochondrial respiration, is depressed in patients with biguanide intoxication. METHODS Multicentre retrospective analysis of data ...
متن کاملThe Dramatic Recovery of a Patient with Biguanide-associated Severe Lactic Acidosis Following Thiamine Supplementation
Biguanides are a drug of choice for the treatment of type 2 diabetes mellitus. Although they can cause lactic acidosis in susceptible patients with predisposing risk factors, the incidence of lactic acidosis is reported to be very low when they are used properly. We herein present a case of biguanide-associated severe lactic acidosis complicated with thiamine deficiency that was provoked withou...
متن کاملLactic Acidosis
Lactic acidosis is a form of metabolic acidosis due to the inadequate clearance of lactic acid from the blood. Lactate is a byproduct of anaerobic respiration and is normally cleared from the blood by the liver, kidney and skeletal muscle. Lactic acidosis occurs when the body's buffering systems are overloaded and tends to cause a pH of ≤7.25 with plasma lactate ≥5 mmol/L. It is usually caused ...
متن کاملLactic acidosis.
A 33-year-old male was admitted to Michael Reese Hospital and Medical Center for evaluation of weight loss, dyspnea, and fever. He had factor Vill-deficient hemophilia and had been chronically ill over several months with a cough productive of scanty sputum, weight loss of 15 Ibs, low-grade fever, and progressive dyspnea on exertion. The medical history was notable for right total hip replaceme...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 1978
ISSN: 0012-186X,1432-0428
DOI: 10.1007/bf01263444